Breast cancer is a big deal, and if you have it then you want to do everything to make sure the treatments you’re taking are actually working, so here is a simple, effective way to prevent tamoxifen resistance – please tell every woman you know! Nobody knows if this will prevent resistance 100%, but according to this study published in the journal Cancer Research, not adding this one simple step can make the drug ineffective, and it’s something that seems harmless. Nobody would ever think this would make such a big difference for breast cancer, but it does so spread the word to your girlfriends – because the killer might be sleeping with your lights on, even a small amount of light under a doorway might cause tamoxifen resistance.
If you know ANY woman with Breast cancer who is using Tamoxifen as a treatment make sure she knows this one simple step. You can help to save her from Tamoxifen resistance. Tamoxifen resistance happens when melatonin levels are too low, and that can be triggered by tiny amounts of nighttime light. Make sure women taking Tamoxifen are also taking melatonin at bedtime and sleeping in TOTAL dark.
It’s completely crazy that this might make such a huge difference, but the research is clear. Exposure to even small amounts of light at night can shut off melatonin production and if there isn’t enough melatonin then the breast cancer is rendered completely resistant to Tamoxifen. Researcher David Blask explains the mechanism this way:
“High melatonin levels at night put breast cancer cells to ‘sleep’ by turning off key growth mechanisms. These cells are vulnerable to tamoxifen. But when the lights are on and melatonin is suppressed, breast cancer cells ‘wake up’ and ignore tamoxifen,”
This has huge implications for women who work night shifts, women who sleep with a TV or computer on in their room or even women who have LED lights or even alarm clocks with lit faces. Also for women who have poorly regulated sleep to begin with or who may not produce adequate melatonin. To me, the simple solution is to include melatonin into the protocol for every woman undergoing breast cancer treatment. Especially since melatonin has it’s own anti-cancer benefits. The standard starting dose for melatonin is 3 mg at bedtime, but in cancer research doses of 20 mg have been shown to have potent anti-cancer benefits, especially for solid tumors like those in breast cancer. If you currently have cancer please talk with your doctor about this and make sure your doctor is aware of the research because this is a new development. Make sure all your lady friends know too because we want to save the ta-tas.
This study was conducted at Tulane University School of Medicine.