MTHFR C677T Superpower: Prostate Cancer Protection.

There could be benefits of MTHFR C677T mutation. Who knew? © Patrimonio Designs Limited | Dreamstime Stock Photos

There could be benefits of MTHFR C677T mutation. Who knew? © Patrimonio Designs Limited | Dreamstime Stock Photos

I am so happy to report that the MTHFR C677T mutation now comes with a superpower, and it’s prostate cancer protection.  It’s not quite X-Men worthy and I have to admit mind control might be a bit cooler, but protection against one of the most common forms of cancer is nothing to scoff at.

The association between MTHFR mutation and prostate cancer has been unclear, with some studies showing increased risk, some studies showing no change and some showing decreased risk, so the information can be difficult to wade through. A recent research study conducted in Shanghai and published in Scientific Reports shows that C677T polymorphisms, whether they are homozygous or heterozygous, are actually protective against prostate cancer although they are quick to say that this study was conducted on the Han Chinese population in Shanghai and that the results may be different for different ethnic groups.

The study shows that intracellular homocysteine levels are slightly elevated when the C677T mutation is present and that elevated homocysteine actually helps to encourage damaged cells, such as precancerous and cancerous cells, to die off the way they should, rather than proliferating into full blown cancer. In unfortunate news, a recent meta-analysis published in Genetics and Molecular Research, showed that this association may not exist in caucasian males and that in this population C677T mutation may not have any effect on prostate cancer. Interestingly, this same meta-analysis showed that the A1298C mutation might have a slight protective effect against prostate cancer in European males.

The most important thing to remember, is that almost every mutation that exists in humans or animals has a double edge – it often has some drawbacks, but typically benefits too or the members of the population with that mutation would die out.  MTHFR seems to be, if anything, becoming more common so I suspect in years to come we will find many other benefits associated with it.

2 thoughts on “MTHFR C677T Superpower: Prostate Cancer Protection.

  1. John Henao

    Hello AMy hope all is well. Long time no talk. I’ve been feeling alot better from the last time we spoke. Im around 80%. After visiting a slew of doctors and doing research myself, I found out that the trigger of all my symptoms was inflammation due to mold toxicity.

    Anyhow I wanted to reach out to you, but your email system was not working. Wanted to go over with you some labs. My folate level was at 24 and B12 was 790 and homocestine was at 6.7.

    How can I reach you.

    1. amyneuzil Post author

      Hi John,
      I’m so glad you’re doing well! My email *should* be working – try and if that doesn’t work, then I’ll send you a different one. I’ll try sending one to you too. 🙂

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